681 Clinical trials in hidradenitis suppurativa and psoriasis under-represent certain gender, ethnic, and racial groups
نویسندگان
چکیده
Hidradenitis suppurativa (HS) and psoriasis (PsO) are inflammatory skin conditions with distinct demographic profiles. We sought to determine whether gender, ethnic, racial profiles of clinical trial patients match those HS PsO populations, although it is unknown demographics change treatment response. identified completed phase II-III trials starting after January 1, 2010 from the US National Library Medicine (ClinicalTrials.gov) on systemic therapies for in adults. found 142 10 collected ethnicity, race participants. combined each disease used chi square analysis differed between general patient populations. For HS, we estimates a study 13,885 (Kilgour et al. 2021). PsO, studies 27,220 (Stern 2004) 12,625 (Armstrong 2021) survey respondents, including 601 379 respectively. these datasets estimate gender latter ethnicity PsO. under-represented females (HS: 63.7% [95% CI: 61.4-66.0%] vs. 73.5%, p<0.001; PsO: 33.0% 32.6-33.4%] 57.6%, p <0.001). Hispanic (3.8% 1.4-6.2%] 12.0%, <0.001) Black (9.1% 6.3-11.8%] 20.3%, p<0.001). over-represented White (76.6% 72.5-80.6%] 59.9%, p<0.001), Asian (12.4% 11.9-12.8%] 4.3%, Other differences were 4% or less. Limitations include comparing populations demographics, as some international, excluding topical therapies, likely skewing our sample toward more severe patients.
منابع مشابه
Hidradenitis suppurativa.
BACKGROUND Hidradenitis suppurativa is a chronic, recurrent, suppurative cutaneous disease. Despite its incidence, optimal medical or surgical treatment remains unclear. This review describes the disease, ranging from pathogenesis to treatment and prognosis. METHODS Articles were sourced from PubMed and Medline, using the MeSH terms 'hidradenitis suppurativa' and 'acne inversa'. Selection of ...
متن کاملHidradenitis suppurativa.
Hidradenitis suppurativa is a chronic, relapsing, inflammatory disease process that primarily involves the axilla and/or inguinal region and does not manifest itself until after puberty. Typically, the process begins as a local occlusive disease of a sweat gland; secondary bacterial infection then occurs. The early stages of hidradenitis suppurativa are usually managed by the dermatologist. Onc...
متن کاملHidradenitis suppurativa
Hidradenitis suppurativa is a chronic disease characterized by recurrent, painful, deep-seated, rounded nodules and abscesses of apocrine gland-bearing skin. Subsequent suppuration, sinus tracts and hypertrophic scarring are its main features. Onset is usually after puberty, although it is most common during the third decade and may persist in old age. The disease tends to be chronic and may de...
متن کاملHidradenitis suppurativa: pathogenesis and management.
Hidradenitis suppurativa (HS) is a chronic disease manifested by recurrent abscesses, sinus tracts and scarring. It arises most commonly, however, not exclusive from apocrine gland bearing skin. This review article sets out to clarify the importance of early diagnosis, the pathogenesis and aetiology of HS, and evidence for medical and surgical therapies for this debilitating disease.HS is cause...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.05.692